From Chapel Hill via 15/501 (Approaching Durham from southwest)
- 15/501 North towards Durham
- merge right onto 15/501 Bypass
- exit onto Hwy. 751 (a.k.a Cameron Blvd.)
- turn right at bottom of exit ramp onto Hwy. 751
- proceed on Hwy. 751 to third stop light, turn left onto Duke University Road
- follow Duke University Road to second stop light, turn left onto Anderson Street
- after first intersection, main entrance is 150 yards on left (half-circle drive with stone walls)

From Raleigh/Cary via U.S. 70 (Approaching Durham from the east)
- U.S. 70 west to merge with I-85 South
- proceed on I-85 South, exit Hillandale Road
- at top of exit ramp, turn left onto Hillandale Road
- Hillandale Road will merge with Fulton Street at the Hwy. 147 overpass
- proceed on Fulton Street to the Erwin Road intersection
- turn left on Erwin Road
- proceed to second stop light, turn right onto Anderson Street
entrance is about one-half mile on the right (half-circle drive with stone walls)

From Raleigh/Cary via I-40 & Hwy. 147 (Durham Freeway) (Approaching Durham from the east)
- I-40 west to Hwy. 147 (Durham Freeway) split
- follow Hwy. 147 into town, exit Swift Avenue
- turn left onto Swift Avenue
- proceed to Campus Drive (four-way stop), turn right onto Campus Drive
- proceed to first stop light and turn right onto Anderson Street
- main entrance is 150 yards on left after the intersection (half-circle drive with stone walls)

From Burlington via I-85 (Approaching Durham from the west)
- I-85 North to Durham
- exit onto Hillandale Road, turn right at the top of exit ramp onto Hillandale Road
- continue on Hillandale, which will merge with Fulton Street at the Hwy. 147 overpass
- proceed on Fulton Street to the Erwin Road intersection
- turn left on Erwin Road
- proceed to second stop light, turn right onto Anderson Street
entrance is about one-half mile on the right (half-circle drive with stone walls)

From points north via I-85
- I-85 South to Durham
- exit Hillandale Road
- turn left at top of exit ramp onto Hillandale Road
- continue on Hillandale, which will merge with Fulton Street at the Hwy. 147 overpass
- proceed on Fulton Street to the Erwin Road intersection
- turn left on Erwin Road
- proceed to second stop light, turn right onto Anderson Street
entrance is about one-half mile on the right (half-circle drive with stone walls)